Interestingly, Wistar rats that display a high susceptibility for the dopamine receptor agonist apomorphine, the so-called apomorphine-susceptible (APO-SUS) rats [4], [5], show an impaired vasorelaxation to adrenergic stimuli when compared with their phenotypic counterparts APO-UNSUS rats [6], [7].
Occasionally, these CoNS isolates display a reduced susceptibility to glycopeptides.
We therefore investigated whether the OCRL1-deficient mutant embryos display a similar susceptibility to heat-induced seizures.
Because earlier work has shown differential rodent strain neurodegeneration susceptibility to neurotoxin [ 22], we then investigated whether two common laboratory rat strains, i.e., Sprague Dawley and Wistar, would display a different susceptibility to hα-syn overexpression.
A subsequent study showed that Fbxw7 is a haploinsufficient tumor suppressor gene, as Fbxw7 +/− mice display a greater susceptibility to radiation-induced tumorigenesis with the wild-type allele being retained and expressed.
Although C. albicans induced LC3-II formation in macrophages, myeloid cell-specific ATG7 mice with defects in autophagy did not display an increased susceptibility to disseminated candidiasis.
Thus, low-birth-weight babies due to adverse foetal conditions often display an increased susceptibility to develop a metabolic syndrome when submitted to plentiful conditions later in life [4], [5].
Smokers and alcohol abusers display an increased susceptibility to bacterial infections, especially those involving the lung.
5 In addition, patients with AD display an augmented susceptibility to cutaneous bacterial, fungal, and viral infections.
Furthermore, Mycobacterium tuberculosis-infected mice lacking T-Bet display an increased susceptibility to disease, most likely due to an IFN- γ/IL-10 imbalance [ 45].
