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Although aggregation-prone regions are thought to occur in the antigen binding region to drive hydrophobic binding with antigen, we were able to rationally design variants that display a marked decrease in aggregation propensity while retaining antigen binding through the introduction of artificial aggregation gatekeeper residues.
Upon cold exposure, 3T3-L1 fat cells display a marked decrease in miR-34a and an increase in browning-related genes, such as those encoding UCP1, PGC-1α and PRDM16.
In contrast, ALT cells depleted of Ku70/80 display a marked decrease in the levels of t-circles, a prominent feature of ALT cells that has been implicated in telomere maintenance.
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Twenty isolates displayed a marked decrease in azole susceptibility.
The crystallinity of PLLA in the blends displays a marked decrease with increasing PVPh content.
wrky-like-1 displayed usually low values for the segregation ratios, displaying a marked decrease in heterozygote individuals detected.
NAD-ICDH displayed a marked decrease in P. fluorescens and HepG2 cells exposed to metal and oxidative stress (Figure 5).
SK-BR-3 cells treated with small interfering RNA (siRNA) targeting EZH2 displayed a marked decrease in EZH2 expression, and a corresponding decrease in bulk H3K27me3 (Figure 4C).
Vehicle-treated rats with an L5 nerve injury displayed a marked decrease in paw withdrawal threshold at the ipsilateral side after nerve injury (p<0.001) (Fig. 1B).
With most olfactory tasks, both AD and control mice displayed a marked decrease in performance between testing at 15 and 18 months of age.
In all cases, HPV-16 E7-expressing cells displayed a marked decrease not only in the multimeric oxidized form, but also in the monomeric oxidized form of GSTP1 (Figure 6A).
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CEO of Professional Science Editing for Scientists @ prosciediting.com