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In addition to the overall island displacement, studies of local displacement have reported new displacement phenomena.
Andresen and Malleson [6] claim these prior displacement studies had measurement issues making identification of displacement difficult.
Miscible displacement studies showed that almost all the soil water was mobile and transport was related to physical equilibrium conditions.
To validate target engagement, blocking and displacement studies with mGluR1 antagonist YM-202074 (20mg/kg; i.v.; 2min before and 30min after tracer injection, respectively) were performed.
For the displacement studies, unlabeled compounds (VUIIS1008 and DPA-714, 1 mg/Kg) were injected 20 min after the injection of [18F] VUIIS1008.
Displacement studies using [3H]folic acid and the non-radioactive reference compound 6 were carried out according to the previously described procedure [18].
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A displacement study assessed specificity of tracer binding.
For the displacement study, four out of ten mice were injected with unlabeled CLINDE (10 mg/kg) at the 82th minute post-injection of the labeled tracer.
One rat from the displacement study was used to perform ex vivo immunohistochemistry for TSPO receptor expression at day 7 after cerebral ischemia.
A displacement study confirmed the specificity of tracer binding on TSPO as about 78% of the activity in the tumor was displaceable by the unlabeled compound.
The support displacement study consists of an inverse analysis aimed at determining the actual present state of the structure from the cracking pattern observed on the bridge.
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