Sentence examples for displacement of endogenous from inspiring English sources
For competitive displacement of endogenous AVP and for receptor binding, slides were incubated (60 min, RT) with the AVP V1a-R antagonist 125I-lin AVP (NEX310, NEN DuPont, Boston, MA; 200 cpm/µl).
Interestingly, PD153035 is, to our knowledge, the only compound capable of activating mitochondrial K+ uptake in the absence of added ATP or ADP, possibly due to displacement of endogenous adenine nucleotides.
It was shown previously that the same mechanism, namely DNA-binding displacement of endogenous OAZ by hOAZzf6-13, was responsible for attenuation of Bmp-mediated activation of Xvent-2 [13].
Displacement of endogenous PTEN by the tail-only domain would also prevent regulation of these processes and potentially prevent EMT.
This might merely be due to overexpression and displacement of endogenous SENP1, but might also have an important role.
That the negative effects caused by the displacement of endogenous myosins by GFP-MYA2-head6IQ molecules are comparable low may be explained by different scenarios.
Irrespective of the explanation, the nearly complete displacement of the endogenous p24 proteins implies that in the p24α3- and p24δ2-transgenic Xenopus melanotrope cells the p24 system consists essentially of only the p24α3- and p24δ2-transgene product respectively.
In the transgenic melanotrope cells, the relatively high amount of newly synthesized transgene product will occupy most of the available space, consequently leading to the displacement of the endogenous p24 proteins.
Here we find that transgene expression of p24α3 or p24δ2 specifically in the Xenopus melanotrope cells in both cases causes an effective displacement of the endogenous p24 proteins, resulting in severely distorted p24 systems and disparate melanotrope cell phenotypes.
We showed in the transgenic Xenopus melanotrope cells a nearly complete displacement of the endogenous p24α3, p24β1, p24γ3, p24δ1 and p24δ2 proteins by both the p24α3- and the p24δ2-transgene product.
Additionally, when mutant human PS1dE9 is overexpressed, it competes for other cofactors of γ-secretase (nicastrin, Pen2, Aph1) causing a displacement of the endogenous PS1 from this complex [ 26, 44].
