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The dispersion of mESCs in each culture condition is smaller than the dispersion between cells in the blastocyst.
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Specialized filopodia, termed cytonemes, have recently been suggested to function as conduits for morphogen dispersion between morphogen-producing cells and their target tissue (reviewed by Kornberg and Roy, 2014).
This analysis revealed significant increases in the distances between cells, i.e., NPC dispersion, in the schizophrenia organoids.
For each ROI, Minimum Spanning Tree graphs were generated (Fig. 2, c1, c2), which showed significant increases in the distances between cells, i.e., increased NPC dispersion, in the schizophrenia organoids (Fig. 2, c3).
These data were normalized with maximum aggregation and dispersion at −1 and +1, respectively, to minimize the variation between cells, and a photosensitivity curve of mean normalized sensitivity against wavelength was plotted.
Increase of dispersion of stiffness values for cells that were cultured for 1 h as compared to dispersion of stiffness values for cells that were cultured for 24 h suggests that interactions between cells and particles are in their active phase.
Cell recognition between cells.
Dispersion of cells into parenchyma occurred in one single recipient animal at a 100 200 µm distance (Supplementary Fig. 2f).
They also revealed the connections between cells.
This separation requires leakproof junctions between cells.
Immobilization of suspended cells allows for a 3D dispersion of cells throughout the gel.
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