We show that C. elegans holocentromeres are organized as dispersed point centromeres, consistent with the polycentromere model.
Thank you for sending your work entitled "Holocentromeres are dispersed point centromeres localized at transcription factor hotspots" for consideration at eLife.
The following dataset was generated: Steiner FA, Henikoff S, 2013, Holocentromeres are dispersed point centromeres localized at transcription factor hotspots, GSE44412 ; http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi acc=GSE44412, Publicly available at the Gene Expression Omnibus (http://www.ncbi.nlm.nih.gov/geo/ ).nih.gov/geo/
From the equation, it is clear that if a signal containing N different points is maximally dispersed (all points being different) then the distribution is a flat horizontal line with a maximal entropy of log2 N.
Assume that we simulate independent sequences initialized with over dispersed starting points, each of length, and discard the first samples as the burn-in period.
Motivated by the spare parts distribution system of a major automotive manufacturer in Turkey, we consider a multicommodity distribution problem from a central depot to a number of geographically dispersed demand points.
In the two patients in whom lymph nodes were also included for analysis, widely dispersed data points of FDG and FMISO SUVs were found for lymph nodes.
Although Lantana is widely distributed throughout India, we tried to select fairly dispersed occurrence points to cover diverse ecosystems which are present in the country.
Likewise, if a signal is minimally dispersed (all points being the same) then the distribution is a vertical line with entropy of 0. This is represented by the red vertical dashed line in Fig. 2A.
The model can simulate runoff, sediment and nutrients (nitrogen and phosphorus) loads from the watershed, by taking dispersed and point sources into account.
Overall, the high level of stringency and the potential to search a large library of broadly dispersed random point mutations are the two most likely reasons why we were able to identify subtle surface residues with important structural and functional properties.
