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The assessment of the association between maternal use of medications during pregnancy and pregnancy or infant outcomes often rely on pregnancy medication exposure registries [ 3, 4] and on studies using administrative databases [ 5– 7], registering prescriptions at the general physician prescription level or at pharmacy dispensing level.
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Major inter-provincial differences in POA dispensing levels and qualitative patterns of POA formulations dispensed persisted.
Concretely, POA dispensing levels substantively increased in the study period, except for notable decreases between 2011 and 2012 (see also below).
Throughout each year of the study period, Alberta featured the highest, and Quebec had the lowest total POA dispensing levels; there was a greater than 3-fold difference in annual total POA dispensing between these two provinces.
Furthermore, considerable inter-provincial heterogeneity between the provinces regarding quantities and types of individual POs dispensed continued, including the remarkably substantive (i.e., three-fold) differences in POA dispensing levels between the highest (Alberta) and lowest (Quebec) province.
In all but one province (Ontario), annual total POA dispensing (i.e., weak and strong POAs combined) increased from 2005 to 2012; four provinces (BC, AB, SK, ON; see Table 1 for list of provinces' full names) indicated a decrease in overall POA dispensing levels in 2011 2012.
At the same time, we note the observed key changes in POA dispensing levels occurred prior to the launch of a Canadian 'National Prescription Drug Use Strategy' – a package of recommendations and measures aimed at the prevention, surveillance, treatment and enforcement of POA-related problems assembled by various governmental agencies and non-governmental stakeholders – in 2013 [ 55].
It is the U.N.'s lead development agency, the chief coordinator in the field of almost all the others, loaded with money, dispensing high-level advice along with more than $9 billion per year around the globe some $5 billion of that from its own budget and another $4 billion or so on behalf of other U.N. operations.
The finance and consulting industries are full of people with MBA degrees who have never "done it before" but reap grandiose salaries by moving money from here to there, or by dispensing high-level, arm-waving "advice" that is hardly actionable or rooted in practicality.
Although sanatoriums and hospitals exist in many locations, they dispense a level of medical care far below that considered standard in the West.
Prescriptions issued by clinicians are recorded in the database, but it does not specify whether the prescriptions were dispensed or level of infant compliance with the product.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com