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Monthly dispensing data on all POA types were aggregated to the yearly data.
The IMSB's CompuScript panel is drawn from a representative and stratified base sample of 5,700 retail pharmacies (representing about two-thirds of the total of retail pharmacies) across Canada, from which a continuously refreshed sub-sample of 65% are providing pharmaceutical dispensing data on a monthly basis [ 31, 32].
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But as it moves from a provider of market data to an executor of trades, Nasdaq's exclusive license to receive and dispense data on all orders gives it a competitive advantage.
Drug dispensed data on the PBS database were used in research studied and shown to represent trends of drug utilisation in Australia [ 30, 31].
Approval to access dispensing data for the HCG was given on the basis that pharmacists have routine access to this data about their patients via the dispensing program and would use it in normal practice to routinely check their patient's history for actual or potential medication-related problems.
We imputed missing dispensing data based on this assumption.
Our dispensing data contained no information on the diagnosis that may have influenced the likelihood the patient may have referred to medicals.
This selection is based on dispensing data and most inclusion and exclusion criteria are incorporated.
DDDs were calculated monthly based on dispensing data from the pharmacy system (PharmaNet Inpatient, Cerner Corporation, Kansas City, MO, USA).
Thirdly, misclassification bias was minimised by looking at those who had been dispensed at least two prescriptions of statin thus increasing the likelihood of compliance even though drug use was reliant on dispensing data.
Overall, the risk of information bias is considered low in this study compared to other real-world studies where the daily insulin dose is calculated based on dispensing data [ 19- 21].
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