We speculate that this relationship may ultimately contribute to their accelerated and disparate disease progression, which is observed later in the course of CKD.
Complex interactions of the genome architecture on lineage selection may be expected when modifications of the genome architecture have multiple and possibly opposed effects which manifest themselves at disparate times and progression stages.
These simple examples of lineage selection effects certainly do not warrant the elaboration of a new systems approach of the carcinogenic process but more complex interactions of the genome architecture on lineage selection may be expected when modifications of the genome architecture have multiple and possibly opposed effects which manifest themselves at disparate times and progression stages.
A systems-level examination of the transcriptional landscape of CLL has the potential to reveal subsets of patients with disparate risks for CLL progression.
While CIA is a reliable model of RA which continues to be used successfully in the development of therapeutics, our data clearly demonstrate that a single injection of MSCs from different genetic backgrounds has disparate effects on disease progression as demonstrated in clinical scores and serum cytokine levels.
Second, recently developed tools that provide a prediction of the time course to end stage renal failure [ 22, 31] if based on a single value, would provide widely disparate estimates of the probability of progression.
It is also noteworthy that sustained activation of the Gq pathway often leads to mitogenesis in a variety of cell types [ 21] with disparate mechanisms of regulating cell cycle progression [ 22].
The progression over 40 years reveals how disparate groups of scientists and disciplines merged and borrowed from each other to produce synergy in research.
But again Vermeer trumps, this time with "The Little Street," with its orderly progression of brick surfaces and forms; the disparate activities but shared concentration of the four figures, which mirror his own; and the creamy, loosely indicated cobblestones rendering the canvas soft and open at its bottom edge.
Such a pathway may not be exclusively limited to breast cancer [ 20], given that deregulated Notch signaling has been implicated as a driver of disparate malignancies [ 15], as promoting aberrant cell cycle progression [ 41], and associated with unfavorable outcome [ 18].
