Using flux variability analysis of a genome scale metabolic network of Streptomyces coelicolor, a series of reactions were identified, from disparate pathways that could be combined into an actinorhodin-generating mini-network.
Thus, to fully understand the metabolic landscape of T2DM, it is necessary to comprehensively determine how multiple pathways change in this condition and to evaluate how disparate pathways interconnect.
However, it may be that these two disparate pathways are more related than initially expected.
The network has five separate pathways without identification of cross pathway hubs involved across the disparate pathways.
First among these complexities is the breadth of social policies that, by nature, affect individuals and communities as a whole through a variety of disparate pathways [ 25].
These approaches have also revealed that cross-regulation among disparate pathways occur [ 3], and is thus desirable to explore regulation at a genome scale.
With the advent of systems biology, scientists are finding interplay between seemingly disparate pathways that are far more significant than originally expected.
It is believed that the exact temporal and spatial extent of the transient Ca2+ elevation explains how this single ionic species can coordinate these disparate pathways.
Rapamycin did not alter RCAN1 levels in Ctrl mice, suggesting that the effects of rapamycin on calcineurin activity are mediated by disparate pathways in unlesioned and lesioned mice.
Third, it is possible that all of these seemingly disparate pathways will converge on a single critical pathway, so that either a single targeted therapy or a multi-component, multi-targeted approach may be effective.
Eight genes are common to all three lists although they encode proteins from a number of disparate pathways (cj0231c (NrdF), cj0545 (HemC), cj0707 (KdtA), cj0810 (NadE), cj0855 (FolD), cj0895c (AroA), cj1644 (IspA), cj1676 (MurB)).
