This is a remarkable combination of peptides considering what is so far known about the disparate functions of these peptides [24], [34], [35].
This result, although unexpected, is consistent with previous data on the disparate functions of glia and neurons in mediating the response to damage, depending on the context – that is, acute focal or remote delayed neurodegeneration.
This study examines the interplay between these two seemingly disparate functions of p57KIP2, and shows that the pro-apoptotic effect of p57KIP2 depends on its ability to stabilize the actin cytoskeleton.
Taking into account the potential disparate functions of MKRN1 in various cell types, we sought to explore the molecular and cellular function of MKRN1 in mESCs using an unbiased systems-level strategy.
The disparate functions of RHAMM are related to its complex subcellular localization.
This highlights the disparate functions of regulatory region methylation with that of gene body methylation [ 54].
The multi-point regulation of Atf1-mediated pathways by the Spc1 kinase provides a mechanistic basis for multiple, seemingly disparate functions of Atf1 (Figure 5).
These anatomical shifts involve changes in both the anterior and posterior regions of the head, and given the disparate functions performed by the posterior region of the skull, which include feeding, respiration and vision, it is likely that it is composed of multiple anatomical modules.
However, in spite of their close physical proximity, the corresponding proteins have disparate functions, raising interesting questions about the evolution of gene function and expression.
These two seemingly disparate functions may be linked, through the involvement of mitochondria in apoptotic cell death.
