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This is a remarkable combination of peptides considering what is so far known about the disparate functions of these peptides [24], [34], [35].
The multi-point regulation of Atf1-mediated pathways by the Spc1 kinase provides a mechanistic basis for multiple, seemingly disparate functions of Atf1 (Figure 5).
The disparate functions of RHAMM are related to its complex subcellular localization.
This highlights the disparate functions of regulatory region methylation with that of gene body methylation [ 54].
This study examines the interplay between these two seemingly disparate functions of p57KIP2, and shows that the pro-apoptotic effect of p57KIP2 depends on its ability to stabilize the actin cytoskeleton.
Taking into account the potential disparate functions of MKRN1 in various cell types, we sought to explore the molecular and cellular function of MKRN1 in mESCs using an unbiased systems-level strategy.
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These disparate functions rely on hosts of regulated interactions that involve survivin and multiple protein partners, including tubulin [ 22, 23] and various chromosomal passenger proteins in the control of mitosis, other IAP family members to counteract apoptosis, and Heat Shock Proteins in the modulation of the cellular stress response.
These anatomical shifts involve changes in both the anterior and posterior regions of the head, and given the disparate functions performed by the posterior region of the skull, which include feeding, respiration and vision, it is likely that it is composed of multiple anatomical modules.
What a lot of people don't understand about the autonomic nervous system is how closely linked all of its disparate functions are.
In addition, the majority of these folds are represented by a number of domains with disparate functions (see Additional file 3) and thus are reasonably robust such that we can discount exaptation as having only a minor effect on our analysis.
However, in spite of their close physical proximity, the corresponding proteins have disparate functions, raising interesting questions about the evolution of gene function and expression.
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