The putative 781-amino acid protein has sequence homologies with a number of proteins of apparently disparate function and cellular localisation.
Therefore, these treatments, especially RP, appear to have much different effects on the proteome and physiology depending on the tissue type, with heart and liver perhaps lying at extremes, considering their disparate function and energetics.
This mechanism provides a new perspective for understanding why TGF- β has disparate functions in vitro and in vivo.
This study examines the interplay between these two seemingly disparate functions of p57KIP2, and shows that the pro-apoptotic effect of p57KIP2 depends on its ability to stabilize the actin cytoskeleton.
This result, although unexpected, is consistent with previous data on the disparate functions of glia and neurons in mediating the response to damage, depending on the context – that is, acute focal or remote delayed neurodegeneration.
Plumage coloration is a prominent aspect of avian visual communication, playing important roles in such disparate functions as crypsis, competition and advertisement, whereby striking or contrasting colour patches often act as inter- and intra-sexual signals of condition and individual quality [1].
These anatomical shifts involve changes in both the anterior and posterior regions of the head, and given the disparate functions performed by the posterior region of the skull, which include feeding, respiration and vision, it is likely that it is composed of multiple anatomical modules.
In addition, the majority of these folds are represented by a number of domains with disparate functions (see Additional file 3) and thus are reasonably robust such that we can discount exaptation as having only a minor effect on our analysis.
One intriguing possibility that arises from the role of the juxtamembrane region in what appear to be disparate functions: ERM-mediated actin cytoskeleton remodelling and ERK signalling, is the additional observation that the same region is also involved in nuclear targeting of dystroglycan [ 64].
The report's biggest package of recommendations is to overhaul the intelligence operations, calling for a cabinet-level national intelligence director within the White House who would control the budgets of all 15 federal intelligence agencies to unify and better coordinate their disparate functions.
