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Monitoring of qPCR-validated miRNAs during GSIS experiments on isolated islets showed disparate expression trajectories between GK and controls indicating distinct short- and long-term glucose dependence.
The disparate expression of pro-metastasis and anti-apoptotic genes in these cell lines may be due to the differential regulation of the promoters of these genes by VDRff and VDRFF.
We were also unable to rescue or increase ErbB2 levels using a specific inhibitor of lysosomal acidification (concanamycin, data not shown), which is at odds with results obtained with chloroquine in the above study by Marx et al. It is possible that differences in cell lines and disparate expression levels of receptors are responsible for these discrepancies.
Our results show a disparate expression of these enzymes.
Whether these differences in induction of apoptosis can be ascribed to the disparate expression level of S100A4 is currently under investigation.
Regarding the spatial distribution of COX expression in the different zones of the growth plate, a disparate expression pattern of COX-1 and COX-2 was observed.
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Or might we benefit from listening to the disparate expressions – both what the brothers' said and how they behaved – and consider how these are incorporated into the mix of feelings we have towards siblings.
Genes with the largest disparate expressions between young and old in SED and EX were involved in vascular function, homeostasis, oxidative stress, and cholesterol (e.g., Col3a1, Emb, Atp2b2, Fmo1, Cyp2e1, Nox4, InhA, Chrna1, and Cyp1a1).
A recent study has shown that although two glioblastoma cell lines (U251 and U87) have disparate gene expression profiles when grown in monolayer cell cultures, they had similar gene expression patterns when grown as intracerebral xenografts in nude mice [ 30].
This provides a mechanism for disparate LRIG1 expression observed in these subtypes of breast cancer and illustrates the importance of context-specific analysis of LRIG1 expression in human cancer.
To date, making comparisons across disparate gene expression platforms has been very difficult [ 5- 8].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com