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It is not clear whether these disorganized structures result from a defect in outer segment formation or stability.
In contrast, mammary cells infected with the miR-142 lentivirus formed disorganized structures with multiple layers of cells.
For example, when normal and malignant human breast cells are placed in 3D cultures of laminin-rich gels, the former cells form growth-arrested, lumen-containing acini and the latter cells form disorganized structures [ 2].
Interestingly, depletion of either nephrocystin-1 or nephrocystin-4 in MDCK cell lines led to severely disorganized structures containing multiple lumens when grown in type-I collagen compared with control MDCK cell lines which formed organized, single-lumen structures (Fig. 5A).
The damaged tissue, next to the bone bridges, is characterized by disorganized structures of the physis and presence of fibrosis.
However, after 24 h, NRP-1 knockdown MSCs produced distinctly disorganized structures, containing significantly fewer branch points compared with control MSCs.
Similar(51)
Tumor vessels are known to have abnormalities showing a tortuous, saccular, and disorganized structure of the vasculature (Fig. 1e).
Moreover, a similar quantitative analysis of midgut epithelial cells from amino acid fed alpha-COPI dsRNA injected mosquitoes, showed highly disorganized endosomal structures and extended regions of swollen RER (Figures 7C and 7D).
RTCB-depleted plasma cells show reduced and disorganized ER structures as well as severe defects in antibody secretion.
Our previous study showed that the fatty acid biosynthetic mutant mod1 displays pleiotropic phenotypes characteristics of typical PCD features, including irregular cell sizes and shapes, disorganized cellular structures, DNA laddering and consequent cell death.
Hepatocellular carcinomas exhibited disorganized cellular structure and irregular borders, with neoplastic cells invading the surrounding parenchyma.
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