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SA's are a heterogeneous group of inherited and acquired erythropoietic disorders with defining features being the presence of bone marrow ringed sideroblasts (RS), abnormal erythroblasts with pathologic mitochondrial iron deposition, and impaired heme biosynthesis [2], [3], [4], [5].
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Early-onset conditions are defined as disorders with clinical symptoms that begin in infancy or childhood, whereas late-onset conditions appear in adolescence or adulthood.
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