Pleiotropic genetic effects have been identified between several disorders which have shared symptoms or are commonly comorbid, using polygenic scores for one disorder to predict another [Purcell et al., 2009].
In a final multivariate model including both type and number of parental disorders, parental panic disorder continued to predict respondent suicidal ideation (OR = 2.5), whereas parental panic disorder (OR = 1.6), generalized anxiety disorder (OR = 2.8) and suicide (OR = 3.0) predicted respondent suicide attempts.
The potential relevance of such factors was demonstrated in a 21-year longitudinal study of young people (Goodwin et al. 2004), in which early presence of anxiety disorders seemed to predict the later development of alcohol dependence.
The uncertainty regarding the ability of mental disorder diagnoses to predict increased HSU means that this review neither refutes nor supports the argument that reliable mental health clusters can be formed by combining broad diagnoses with care pathways, in a simple and practical manner.
A recently developed method is based on the consensus of the distributions of charge-hydropathy values and disorder prediction scores to predict proteins that are mostly disordered [10].
Pryor et al. [ 43] evaluated the performance of 13 disorder predictor programs to predict disordered regions located in integral membrane proteins.
The presence of acute stress has been reported to have a significant effect on seizure control, with several studies showing patients with seizure disorders being able to predict with reasonable accuracy seizure occurrence within the following hours or days.
Anxiety disorders however, continued to predict increased PD risk even when restricting to a lag of over 20 years between the diagnoses.
Comparisons of self-reported perceived levels of disorder with data on physical disorder collected through Street View indicate that virtual audits yield reliable data on physical disorder and allow to predict neighborhood differences in victimization.
44 Externalising disorders (oppositional defiant disorder and conduct disorder) have been shown to predict a worse response to SSRIs and CBT, 44 and there is some suggestion that individuals presenting with this dual diagnosis would benefit from modified treatment approaches, such as CBT combined with parent management training.
