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The coexistence of different primary headache disorders is not rare.
The pathophysiology of secondary CLH associated with pituitary disorders is not well-known.
However, the incidence of post-VMMC bleeding due to bleeding disorders is not known.
However, the extent to which modern treatments have influenced the natural course of mental disorders is not entirely clear.
Optimal management of these MC twin disorders is not yet established; long-term follow-up studies are unsatisfactory.
In Italy, as we noted, the epidemiology of headache disorders is not well established, and data on impact are very few.
Apparently, it has been recognised that having a fundamental change in the clinical intervention of orthopaedic disorders is not a short-term task.
Whether newer MS treatments such as Teriflunomide, Dimethylfumarate or Fingolimod may impact primary or secondary headache disorders is not yet clear.
In children (6 11 years) and adolescents (12 17 years), the prevalence of headache disorders is not well established and the burdens attributable to them are poorly characterised.
The prevalence of anxiety and mood disorders is not specific of migraine, but it might be related to the recurrence of chronic pain disorders [32].
Medical therapy although useful in reducing the severity of other symptoms of endometriosis such as pain and menstrual disorders, is not efficacious to improve fertility.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com