Percentage count for observed frequencies in headache type in child × psychiatric disorders in parents interaction.
Incorporation of additional voices in the consultation creates new forms of order (and disorder) in the interaction.
Protein intrinsic disorder, via diversity arising from structural plasticity or flexibility, provide a means for hubs to associate with many partners (Dunker AK, Cortese MS, Romero P, Iakoucheva LM, Uversky VN: Flexible Nets: The roles of intrinsic disorder in protein interaction networks. FEBS J 2005, 272 5129-5148).
Without specific regard to protein-protein interaction networks, several years ago we considered possible roles of disorder in protein interactions.
While the focus of this paper is on the roles of disorder in the interactions involving two different hub proteins, the DNA binding domain of p53 presents the opportunity to study structural changes involving one structured region binding to several different structured partners.
The order/disorder tendencies of IDPs as revealed by PONDR® VLXT could be used to find disordered region(s) involved in interaction with specific binding partners.
Table 2 lists several domains with high disorder content and shows that these intrinsically disordered domains play crucial roles in interaction with RNA, DNA, and proteins and are important for recognition, regulation and signal transduction.
Moreover, in Fig. 4 percentage count for observed frequencies in psychiatric disorders in parents × frequency interaction was almost significant (partial χ2 = 6.94; df = 2; P = 0.05).
In contrast, in boys the effect of body dissatisfaction on later eating disorder outcomes was seen mainly in interaction with BMI.
Genetic epidemiological studies indicate that schizophrenia is a complexly inherited disorder, whereby multiple genes, additively and in interaction with environmental factors, contribute to increasing risk for phenotypic expression.
