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These cells offer great hope as a preliminary tool for understanding how certain disorders arise and discovering more advanced therapeutics.
Some fatty acid oxidation disorders arise through dysfunction of carnitine transport enzymes, although most of these conditions are caused by fat-degrading enzymes directly involved in the beta-oxidation cycle itself.
Both drugs affect the brain's metabolism of the neurotransmitter serotonin, and this had led researchers to suspect that obsessive-compulsive disorders arise primarily from defects in the brain's neurochemical functioning rather than from purely psychological causes.
Conventionally, the peak at 1352 cm−1 is attributed to the defects, and disorders arise in the sp2 carbon rings (D-band).
Researchers say recording the normal growth trajectory of individual parts of the brain might help them better understand how early disorders arise.
Some sleep disorders arise when the body's drive for sleep--known as the homeostatic drive--and the environment are out of sync.
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But Intellia has a deal with pharmaceutical giant Novartis to focus on cancer and genetic disorders arising in blood cells.
As for block, she thinks the main problem may lie in the frontal lobe, because block shares some characteristics with disorders arising from frontal-lobe damage, such as Broca's aphasia, which destroys the ability to produce normal language.
Duchenne and Becker muscular dystrophies are allelic disorders arising from mutations in the dystrophin gene.
Symptom burden in common headache disorders arises from pain, and, in migraine, additionally from nausea, vomiting and photo- and/or phonophobia.
The need to develop new approaches for treatment of these disorders arises from the fact that conventional therapeutic strategies face many obstacles and limitations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com