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Pope Benedict XVI accused international agencies of promoting abortion in Africa and blamed "disordered notions" of marriage and the family for the spread of sexually transmitted diseases there.
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In-cell NMR data on human tau, α-synuclein and other disordered proteins support this notion (see section 5.2).
For instance, this evidence-base has already aided our shifting away from the long-held perception that EDs are the domain of the wealthy, White, young female toward the notion that disordered eating and body image disturbance are experienced by males and females 15, 16 of all ages 17 and ethnicities 18, 19 and who live in both developed and developing countries.
We considered this as an opportunity to not only test the ability of the forcefield to correctly identify the stably folded parts of a structure, but also to verify (or otherwise) the notion that structurally disordered parts of polypeptides do not contribute significantly to the thermodynamic stability of their folded state [18] [20].
All these observations provide strong support to the notions that intrinsic disorder is abundant in human proteins associated with the p53-mediated apoptotic signaling pathways and that disordered regions are frequently used for protein-protein interactions needed for the efficient control and regulation of the mentioned pathways.
Dunker et al. use this evidence to convincingly argue that the higher evolutionary rates of disordered proteins also lend strong support to the notion that they exist freely in cells.
"The punishment of every disordered mind is its own disorder".
This observation fits well to the notion that phosphorylation sites usually occur within intrinsically disordered protein regions [ 40, 41].
To investigate this notion, Dunker and Lin compared the genetic distances of ordered and disordered protein regions within 26 families.
Although the data presented support the notion that spreading initiates at ordered epitopes and can spread through disordered regions to elicit autoimmune disease, we have said little about how this might occur.
Thus, both intuitions about what makes a good antigen and the computational analysis of predicted MHC II T cell epitopes support the notion that there will be few T cells targeted to extremely disordered regions.
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