Sentence examples for disordered interactions from inspiring English sources

Cdc4 recognizes six different phosphorylation sites of Sic1 and engages the protein in transient, disordered interactions.

In general, the ensemble models indicate details of tight and highly ordered drug target interactions on one side vs disordered interactions elsewhere, which are indicative of less tight interactions, that may suggest which sites to modify in a drug-optimization cycle.

However, unlike normal stem cell niches, which have evolved for millions of years, resulting in a fine-tuned crosstalk between stem cells and their environment, the cancer - or metastatic - niche evolves in a remarkably short time, resulting in more disordered interactions.

Secondly, they have a modular architecture, containing discrete functional units such as globular domains with catalytic or binding activities (1, 17), disordered interaction interfaces such as short linear motifs (18), transcription factor binding sites in DNA (13, 19), protein binding sites in RNA (20, 21) and sites for covalent modification (22 24).

Studies that incorporate genetic factors in combination with neurocognitive testing would benefit from also including the effects of genetic factors on cognitive functioning in healthy individuals since gene-by-disorder interactions might be expected.

Recently, Manoliu et al. found that the aberrance of the rAI may be associated with the disorder interaction between DMN and CEN in schizophrenia [ 2, 12] and major depression [ 13].

This effect was not significant in the extended model which included recent adverse life events, perceived financial difficulty and a marginal interaction of financial difficulty with social capital, suggesting that these variables shared a portion of the variance in psychological impairment accounted for by the social capital and affective disorder interaction.

Although Tau monomers are intrinsically disordered, long-range interactions within the protein could lower the accessibility to the repeats and hence prevent docking of the monomers to the fibril ends.

For these disorder-based interactions, the disordered partner "morphs" from disorder-to-order, and, therefore, some of the binding energy must be spent to overcome the higher entropy of the unfolded state.

These findings suggest that IVV technology can identify both stable and less stable interactions involving disordered regions.

Disordered region-mediated molecular interactions have been proposed to work using a combination of conformational selection and induced folding.