Recently, Manoliu et al. found that the aberrance of the rAI may be associated with the disorder interaction between DMN and CEN in schizophrenia [ 2, 12] and major depression [ 13].
This effect was not significant in the extended model which included recent adverse life events, perceived financial difficulty and a marginal interaction of financial difficulty with social capital, suggesting that these variables shared a portion of the variance in psychological impairment accounted for by the social capital and affective disorder interaction.
Secondly, they have a modular architecture, containing discrete functional units such as globular domains with catalytic or binding activities (1, 17), disordered interaction interfaces such as short linear motifs (18), transcription factor binding sites in DNA (13, 19), protein binding sites in RNA (20, 21) and sites for covalent modification (22 24).
Cdc4 recognizes six different phosphorylation sites of Sic1 and engages the protein in transient, disordered interactions.
Studies that incorporate genetic factors in combination with neurocognitive testing would benefit from also including the effects of genetic factors on cognitive functioning in healthy individuals since gene-by-disorder interactions might be expected.
In general, the ensemble models indicate details of tight and highly ordered drug target interactions on one side vs disordered interactions elsewhere, which are indicative of less tight interactions, that may suggest which sites to modify in a drug-optimization cycle.
Type 1 diabetes (T1D) is a multifactorial autoimmune disorder where interaction and integration of immune response genes along with environmental factors play a role in autoimmune destruction of the insulin producing Pancreatic Beta cells.
The argument can be extended to encompass social disorder, agonistic interactions, or other cues that the environment is generally unsafe [16].
Thus, the p53/Mdm2 complex is not alone in being a disorder-based interaction that is blocked by a small drug-like molecule.
However, this predictor is extremely sensitive to the local peculiarities of amino acid sequences and therefore, is very useful for finding potential disorder-based interaction sites.
In a study examining the behaviour of children with externalising disorders in interaction with their mothers, hyperactivity was enhanced by the interaction between the impulsive behaviour of the child and the aversive maternal response [ 106].
