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The disorder distribution is close to what is predicted for the human proteome11.
For the weak disorder distribution, the measured angles are more important than the predicted angles up to surface coverage of about 60%.
The NFZ constraints pose serious challenges to the guidance design: (1) because there is no engine to provide thrust, the vehicle needs to manage the energy of motion carefully and cannot perform avoidance maneuvers arbitrarily; (2) due to disorder distribution of NFZs, there are multitudinous complicated cases to consider.
If the peculiarities of disorder distribution within the protein sequence are related to protein functionality, then comparison of the disorder profiles of artificial cIFNs (query profiles) with the averaged disorder predisposition profile of human IFNs-α (target profile) can be used in the design of novel cIFNs.
In this respect it is also noted that disorder distribution in ribosomal proteins among bacterial species appears rather at random (Additional file 7: Table S6).
Interestingly, Figure 11 provides some insights into the correlation between the evolution of Archaea and the intrinsic disorder distribution in these organisms.
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Discrete models bring essentially the same qualitative results as continuous ones regarding localization effects, and they are solvable for many disorder distributions.
It is commonly recognized that, during this step, a lot of defects (substitution, interstitial and vacancies) can be created to induce the formation of disordering distribution of C atoms or amorphous carbon, and the Ag-nanoparticles cannot be formed because these atoms are in violent motion.
In patients with and without metabolic disorders, distribution of the G19G, G19A, and A19A genotypes and frequency of the 19A and 19G alleles of the leptin gene did not differ (p > 0.05) (Table 3).
These two distributions have different shape than shape of the disorder content distributions for whole proteins; the fractions decrease with the increase in the disorder content, but then suddenly increase in the 80 100% range.
We compared the disorder content distributions for AS regions for genes from individual classes to the overall distribution for AS regions from all human genes.
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