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The DisProt database of protein disorder (Box 1) lists functions of individual disordered regions, when known from experiments, the major limitation here being the small number of regions for which exact function has been characterized.
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Recently, specialized cultures of iPSCs have generated cerebral organoids, mini-embryonic brain-like structures (Lancaster and Knoblich, 2014), with implications for addressing psychiatric disorders (Box 1).
If it's winter and you work in a cave-like, cubicle set-up where the only windows are hoarded by the executives' offices, a Seasonal Affective Disorder light box might be a good investment.
Finally, the Database of Disordered Protein Prediction (DP, http://d2p2.pro/) stores disorder predictions (Box 3) made by nine different predictors for proteins from completely sequenced genomes.
The burial of hydrophobic patches in part explains why EloBC complex is required for stabilization of the otherwise disordered SOCS-box domain of receptor proteins [ 43].
The special sequence properties of disordered regions are the basis for many disorder prediction methods (Box 3).
Second, the development of disorder prediction methods (Box 3) has led to the identification of segments that promote disorder-to-order transitions called molecular recognition features (MoRFs), which have been verified using known crystal structures.
The results verified that the attachments were destroyed, some spindle fibers were scattered in the cytoplasm, some kinetochores appeared to be disordered; the magnified box region shows details of disruption (Fig.4A).
So far, variants in four specific genes have been associated with spoken language disorders - forkhead box P2 (FOXP2) and contactin-associated protein-like 2 (CNTNAP2) on chromosome7 and calcium-transporting ATPase 2C2 (and2C2) and c-MAF inducing protein (CMIP) on chromosome 16.
Suffering from body dysmorphic disorder (BDD) was like living trapped in a box lined with distorting mirrors.
But the field had become increasingly politicized, and the disorder remained a "black box".
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