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An updated compendium of different techniques employed to evaluate disintegrant action and measure disintegration time is also provided.
Obtained dosage forms were characterized for drug content, disintegration time and mechanical properties.
Batches were characterised for moisture content, granule density, crushing strength, porosity, disintegration time and dissolution.
The quality properties such as friability and disintegration time of the ODTs met the USP specifications.
In all tablets, a linear relationship was observed between tablet hardness and oral disintegration time.
Disintegration time was found to be sensitive to the percentage of hypromellose.
The tensile strength (TS) and disintegration time (DT) of tablets were measured as tablet characteristics.
The study looked at three responses namely; porosity (P), tensile strength (S) and disintegration time (T).
Moreover, tablets' disintegration time was shortened to reach few seconds in some of the formulations.
Final core tablet (C8) was selected on the basis of disintegration time (23.33 ± 2.08 s).
The formulations were assessed on assay, dissolution, friability, weight variation and disintegration time.
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