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During in vitro disintegration tests, β-TCP particles disintegrated from the scaffolds.
Disintegration tests were performed with tablets at different ratios of modified corn starch mixed with caffeine or paracetamol powders.
In vitro dissolution and disintegration tests for both products were carried out in two aqueous media: A) SLS 0.25% and B) HCl/KCl pH 1.2.
The breakdown of failures is as follows: 0.7% (2/281) failed only disintegration tests, 0.4% (1/281) failed only TLC, and 11% (31/281) failed both TLC and disintegration tests (See Table 1).
Having again recorded the better-performing sample in the duplicate pair, 5% (12/260) of tested samples failed TLC and/or disintegration tests.
In total, 541 samples were collected from pharmacies in Delhi and Chennai, with 8.5% (46/541) of tested samples failing TLC and/or disintegration tests.
Similar(48)
The disintegration test revealed that all liquisolid system formulations disintegrated within a maximum of 159 ± 3 s, which complies with the specifications given for the uncoated tablets in the Ph. Eur.
The aim of this study was to develop a responsive disintegration test apparatus that is particularly suitable for rapidly disintegrating tablets (RDTs).
In conclusion, the modified disintegration test device is a valuable tool for biorelevant in vitro disintegration testing of solid oral dosage forms.
The device represents an improved derivative of the compendial PhEur/USP disintegration test device.
A modified in vitro disintegration test device was designed that enables the investigation of the influence of hydrodynamic conditions on disintegration of solid oral dosage forms.
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