Since high expression of E2F1 is sufficient to induce apoptosis in some settings, simultaneous transcriptional activation by c-Myc and dampening of translational efficiency by the mir-17 cluster may tune E2F1 activity such that cell death is disfavoured and proliferation is promoted.
Her judgments were considered the final word in most cases, and her disfavour was feared more than that of any film critic.
One of the reasons style began to be looked upon with disfavour was because it came to be associated with elitism and hubris in a time of disingenuous free-market egalitarianism.
The degree of his disfavour was shown when he was reprimanded for supposedly delaying diplomatic letters.
Bistami goes on to become a judge for Mughal Emperor Akbar, but later falls into his disfavour, being exiled to Mecca.
The idea that any of the TCA cycle enzymes might be poorly active is disfavoured by the presence of two NAD-specific glutamate dehydrogenases in P. carbinolicus: GdhB (Pcar_1237) is 29% identical to a Thermotoga maritima enzyme [ 82] and GdhC (Pcar_1831) is 31% identical to a Streptomyces clavuligerus enzyme with multiple allosteric effectors [ 83].
Triple helix formation is known to be disfavoured in pure oligo-dA tracts, but the insertion of a single central guanine nucleoside has been shown to lead to observable triplex formation at neutral pH [51].
The mortality outcomes of this Continued Access RCT, disfavouring TAVI, were included in our analysis.
A statistical difference favouring or disfavouring GDT was considered to occur if the 95% CI failed to cross the OR = 1 line (equivalent to P < 0.05).
On other hand, many amino acids (ALA, ASP, CYS, GLN, GLU, ILE, LEU, MET, PHE, PRO, and VAL) are disfavoured in the interactions sites.
