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Finally, the transmission disequilibrium test showed evidence for linkage between B2A2 haplotype and schizophrenia.
A total of 224 family trios (672 participants in total) were enrolled in this family-based transmission disequilibrium test.
Head-to-head comparisons with the relevance-chain, multifactor dimensionality reduction, and the pedigree disequilibrium test (PDT) methods were obtained.
To generate the FBAT statistic, three important characteristics of the original transmission disequilibrium test (TDT) are incorporated.
These estimates are then used to construct a rare-variant transmission disequilibrium test (rvTDT) in the case-parent data.
Using a family-based study design we assessed genetic association by means of the haplotype-based haplotype relative risk (HHRR) and transmission disequilibrium test (TDT) statistics.
The transmission disequilibrium test (TDT) showed that of three SNPs, rs10314 in the 3′-untranslated region of the CLDN5 locus was associated with schizophrenia (χ2 = 4.75, P = 0.029).
We developed a RV extension of the generalized disequilibrium test (GDT) to analyze sequence data obtained from nuclear and extended families.
Our Monte Carlo simulations provide evidence that the PGMDR method is superior in performance to identify epistatic loci compared to the MDR-pedigree disequilibrium test (PDT).
They were analysed for association for the remaining SNPs using the transmission disequilibrium test (TDT) [26].
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The data of the proband-parent triads were analyzed by the transmission-disequilibrium-test (TDT) [ 10].
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