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The first refers to the evaluation of FDR and the multiple testing problem, and the second relates to the linkage disequilibrium issue.
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The relation between the Fe-rich and Fe-poor parts is neither a core rim relationship nor a sector zoning but heterogeneity in individual grains, implying disequilibrium crystallization; this issue is addressed in later discussion subsequently.
The third issue regards Hardy-Weinberg disequilibrium for GCLM-588.
Gene-gene interactions, epigenetic effects, and patterns of linkage disequilibrium contained within haplotypes are all issues that must be addressed.
To address this issue, we tested the linkage disequilibrium (LD) between the genomic interval of each of our identified modules and the entire genome.
However, the outlier approach framework that we implemented and that combines three tests that consider three different molecular patterns (namely genetic differentiation, site frequency spectrum, and linkage disequilibrium) is very likely to overcome this issue.
Possible linkage disequilibrium between HLA loci has been a thorny issue when researchers tried to identify the genuine locus responsible for the association signal [11], [15], [17].
Additional issues involve handling genes in linkage disequilibrium and genes residing in multiple pathways.
Disequilibrium could become a significant medical and/or mental health issue.
Price uncertainty is an important issue, and it might reflect the potential for disequilibrium in the energy market (Arrow 1962).
Another drawback to the joint modeling of multiple SNPs within a gene is possible model fitting issues due to multicollinearity between SNPs (ie, linkage disequilibrium (LD)), as well as the lack of inclusion of LD information in the analysis.
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