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Furthermore, recent work that uses orthology between human genes and those in other organisms to find models for human diseases support these results [32], [33], [34].
Studies showing similar findings in tendon and disc diseases support that this pathway is general in connective tissue [ 17, 31].
Multiple case reports about the use of dapsone in a variety of diseases support the assumption of innocuousness.
This study contributes to understanding and improving the processes associated with quality of life, which is relevant for health care providers and chronic diseases support.
Taken together, the results in terms of PTPN22/CSK association with autoimmune diseases support the notion that different pathogenic mechanisms are involved in the development of polygenic disorders.
This study contributed to understanding and improving the processes associated with HRQL, which is relevant for health care providers, and chronic diseases support.
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This study was conducted within the Finnish Centre of Excellence in Cardiovascular and Metabolic Diseases supported by the Academy of Finland, University of Turku, Turku University Hospital, and Åbo Akademi University.
The importance of inflammation and oxidative stress in many chronic diseases supports the concept that activation of anti-oxidant Nrf2 signaling may have therapeutic potential.
Using schizophrenia as an example, we show how intrinsic networks may show similar abnormalities in human diseases and animal models of these diseases, supporting their use as biomarkers in drug development.
Accumulating evidence suggests that oxidative stress resulting in reactive oxygen species generation plays a pivotal role in neurodegenerative diseases, supporting the realization of the use of radical scavengers, metal chelator agents, such as the natural polyphenols for therapy.
The analysis of variability extremes was followed by the study of individual diseases (Supporting materials, section P4).
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