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To survey the quality of evidence-based clinical practice guidelines for chronic respiratory diseases relevant to physiotherapy practice using the Appraisal of Guidelines for Research and Evaluation version II instrument (AGREE II) and to evaluate the inter-rater reliability of AGREE II.
A key aspect will be the possibility to distinguish relevant contacts: for control of sexually transmitted diseases relevant contacts are easily identified (that is, if people are willing to co-operate), but in case of respiratory pathogens like SARS or influenza the notion of relevant contacts is rather diffuse.
Some endemic diseases relevant to public health are notifiable but not subject to systematic surveillance.
The zebrafish is emerging as a useful tool for studying neurological diseases relevant to humans.
At baseline (initial visit), the majority of patients (n = 7350/11,377, 64.6%) had one or more concomitant diseases relevant to AECB.
The cell-type specific enriched regions were strongly associated with functional terms, pathways and diseases relevant to the corresponding cell types.
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In addition to their role as drugs, they are successfully used as molecular probes to identify disease relevant targets.
With genome editing tools, stem cell lines from patients can be efficiently "cured" to correct the disease relevant genetic variants to establish isogenic control groups (Fig. 1A).
Recent advances in biotechnologies have led to an explosion of disease relevant molecular information, providing enormous opportunities to obtain the pathophysiological insights to develop personalized treatment.
Meanwhile, poor biology, lack of disease relevant assay, poor target validation, and lack of biochemical information also lead to the failure of target-based strategy.
To identify disease relevant genes and pathways associated with knee Osteoarthritis (OA) progression in human subjects using medial and lateral compartment dominant OA knee tissue.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com