Inclusion criteria included: histologically documented recurrent epithelial ovarian cancer confined to the peritoneal cavity (no extra-peritoneal disease), possibility of an optimal CRS aiming to remove all tumour nodules, age over 18, WHO performance status 0 or 1, life expectancy ⩾3 months, and normal haematological, renal and hepatic functions.
In line with the current interest in protein kinases inhibitors as potential drugs against a variety of diseases, the possibility that protein kinases may represent targets for novel anti-parasitic agents is being explored.
Internet-based interventions are very attractive because they address an important issue in the management of chronic diseases: the possibility of systematic training in self-management strategies.
In any disease but most especially in rare diseases the possibility of accessing detailed patient datasets from research and clinical studies, including genetic variants and phenotypic manifestations, would significantly improve diagnosis and treatment.
Although efforts were made to exclude dogs with respiratory, inflammatory, immune-mediated, neoplastic or infectious diseases, the possibility cannot be excluded that these dogs might develop such disease later in life.
14 The authors hypothesized that the pathophysiological mechanisms underlying iron deficiency in heart failure are markedly different from those in chronic inflammatory diseases, a possibility that requires further evidence to be confirmed.
Therefore, a mathematical model of the disease is needed to study the behavior of the disease and possibility of control.
When a liver nodule is found in middle-aged women with an autoimmune disease, the possibility of RLH should be considered.
While high ferritin with normal serum iron and normal transferrin saturation is expected in Gaucher disease, the possibility of concurrent genetic haemachromatosis should be eliminated.
Though no history of drug intake could be elicited in our patients before the onset of renal disease, this possibility cannot be completely ruled out in idiopathic cases.
