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In this review, various systemic reactions associated with immune stimulation will be addressed, including: APR, hypersensitivity, induction or worsening of autoimmune diseases, modification of hepatic metabolism and vascular leak syndrome (VLS), with an emphasis on the mechanism involved.
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To assess if the fetal electrocardiogram especially ST segment is modified by congenital heart diseases: modifications in frequencies of the different ST events and modifications in signal quality.
Reduction of Hcy to normal levels therefore presents a new approach for disease modification.
Incorporation of a biomarker into clinical trials will support the claim for disease modification.
The era of disease modification as a therapeutic option for Alzheimer's disease (AD) is upon us.
The concept of disease modification in Alzheimer's disease is controversial and the design of these trials raises many questions.
TET2 appears to be mutated in primary human samples in aggressive types of SM, suggesting a possible role in disease modification.
The ability of sitagliptin to enhance islet cell function may offer insight into the potential for disease modification.
Disease modification of epilepsy refers to the alleviation of epileptogenesis or comorbidities after genetic or acquired epileptogenic brain insults.
Disease modification can be defined as treatments or interventions that affect the underlying pathophysiology of the disease and have a beneficial outcome on the course of AD.
In addition, the Task Force identified two main categories of outcomes in rehabilitation clinical trials, which include outcomes related to symptoms and function, and outcomes related to disease modification.
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