Seventeen patients with poor risk Hodgkin's disease from a single centre underwent autologous bone marrow transplant (ABMT) using high dose melphalan and etopside conditioning.
The consistency is notable because the three studies used entirely different sampling approaches to define the study populations: reports of occupational disease from a single clinic [ 23], a survey of the general population in one state [ 31], and a survey of a single corporate workforce across several states (the present material).
In fact, we have seen CVR improvement in severe bilateral MMD (occurring in 11 of 13 patients; patients 3 and 4 did not improve) as well as in steno-occlusive disease from a single bypass (occurring in 5 out of 7 patients; patients 5 and 15 had reduced CVR following bypass).
Interestingly, the degree is not correlated with the number of sources for a given disease (not shown); most diseases come from a single source, whereas some arise from as many as 12 sources.
This model facilitates the conceptualization of hypotheses regarding multiple causes contributing to a single disease of interest and addresses such issues as multiple diseases arising from a single cause and multiple causes for a single disease with distinct models of susceptibility and biologic interactions, as well as background risk due to endogenous processes or other exposures.
Third, findings were made in predominantly elderly patients with high prevalence of comorbid diseases and from a single centre only.
To summarize, our analysis established a link between human phenotypic disease network and protein evolution, which will definitely help in understanding human monogenic disease etiology and the underlying mechanism of disease progressions from a single gene.
In less than six weeks, the disease spread from a single British piggery to over 750 farms and upward of 764,000 animals.
The diverse presentation of disease resulting from a single environmental exposure, cigarette smoke, suggests the presence of distinct bio-molecular and cellular pathways leading to a divergence of anatomic phenotypes.
This risk can be limited by using disease data from a single source.
