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Similar results have been reported in other complex diseases: for example, in breast cancer [3] the top 11 SNPs at final validation stage (involving 21,860 cases and 22,578 controls) have ORs ranging from 1.04 to 1.26.
The "control dataset 2" was constructed to ensure that "unstructuredness" may not be necessary for all the genetic diseases, for example in metabolic disorders, where the involved proteins are predominantly structured enzymes.
The approach to change the ratio of naturally occurring isoforms has been tried to develop treatments for several diseases, for example, in cancer.
In a number of brain diseases, for example, in diffuse axonal injury resulting from traumatic brain injury and in frontotemporal dementia, patients are not aware of inappropriate behavior.
Callosal demyelination is observed in many neurometabolic diseases, for example, in globoid leukodystrophy (Krabbe disease), metachromatic leukodystrophy, leukoencephalopathy with vanishing white matter, and mitochondrial diseases.
How can exposure to light and darkness be optimized to reduce the risk of cancer and other diseases, for example in shift workers?
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In some diseases, for examples in acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML) and cardiac hypertrophy, all the three members are highly expressed.
In Hashimoto's disease, for example, in which the immune system assaults the thyroid gland, the proportion of female to male victims is 50 to 1.
Mast cell expression is increased in cardiovascular disease, for example in atherosclerotic lesions.
Where a graded effect was observed within a disease, for example, in diabetes or malignancy, these diseases were further stratified according to their severity.
CN losses within 11q have been reported for many cancer types and have been associated with metastatic disease for example in pheochromocytoma [ 32].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com