Genetic factors are important in the development of autoimmune disease, since such diseases develop in certain strains of mice (e.g., systemic lupus erythematosus or lupus in MRL mice) without any apparent infectious environmental trigger.
These OECD regulatory test protocols are stuck in the age of the light microscope, test a narrow and unrealistic portion of the dose response curve and relatively few end points, mostly fail to test toxicity during vulnerable development, and kill the animals being tested before most diseases develop (a human equivalent of ~ 60 years).
Such research is one promising way to learn how the diseases develop and devise the best treatments.
"So now we can get a better understanding why such diseases develop".
"It has become an amazingly powerful tool to dissect the molecular basis for why these diseases develop and to help us ways to breed out complex inherited diseases".
Doctors believe that the diseases develop when a normal protein found on the the surface of cells somehow misfolds into an abnormal shape.
Their purposes in creating the cell lines, which require making an early human embryo, are to study how the diseases develop and also to see if replacement cells can be generated to repair the patient's own degenerating tissues.
Most such diseases develop after a variable period during which that part of the nervous system subsequently affected apparently functions normally.
But when it is over, it is likely to have changed people's views about how cells regulate themselves, how life becomes more complex, how certain mysterious diseases develop and even how the process of evolution operates.
You'll have a working knowledge of how diseases develop and how this affects the function of the body, as well as being able to identify risks –if you spray a field with a certain chemical, could it damage eyesight, for example – and how they can be prevented.
These diseases develop earlier among underprivileged people.
