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There is increasing interest in tissue or cell type-specific gene expression analysis to identify genes involved in diseases, cell fate determination, or response to external stimuli.
Retrievable information include gene expression, signaling pathways, cell types, developmental stages, anatomical compartments, differentiation protocols, diseases, cell therapies, and literature references.
After initial gene name identification, the most recent 100 gene-annotated documents were manually examined to reduce ambiguous gene symbols that may represent genes, diseases, cell lines, experiment techniques or other terms simultaneously.
The complex and poorly understood natural history of HIV infection necessitated rigorous longitudinal follow-up and in-depth characterization of the participants (e.g., demographic characteristics, clinical characteristics, co-morbid diseases, cell repository) enrolled into natural history cohorts.
Life science has become a data rich science with information about the behaviour of millions of entities like genes, chemical compounds, diseases, cell types and organs, which are organised in many different databases and/or spread throughout the literature.
When used to monitor the change of biochemical functions of living biological cells in the period of the treatment and rehabilitation of diseases, cell impedance analysis provides a functional model that can be used to evaluate cells by applying physiology and pathology information [ 11].
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Some scientists say drugs will work better for some diseases, cells for others.
In many diseases, cells derived from normal ESCs can be used to study diseases and new drugs.
In neurodegenerative diseases, cells succumb to an overload of toxic protein aggregates.
This approach allows for the efficient and rapid formation of genetic LOF human disease cell models with isogenic controls.
Based on physiological similarity and hierarchy, pathways were classified into several groups including immune system, signal transduction, metabolism, disease, cell cycle and hemostasis (Fig. 2).
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