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Studying how this is performed in a context and cell type specific way is essential to understand signaling both in physiological and diseased situations.
This is an important feature for any liver segmentation approach to be applied for cancer treatment and especially SIRT since the size of the liver is greatly affected in diseased situations.
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In particular, GO only describes the normal, physiological function of a protein, rather than the pathological function of a protein in a diseased situation.
In disease situations, abnormally behaving cells are surrounded by heterogeneous tissue elements, and the areas of interest/diseased cells may constitute less than 5% of the volume of a sample.
Although regulations call for culling of diseased animals, certain situations e.g. wild life conservation, highly valuable breeding stock, could benefit from effective treatment schemes and post-exposure prophylaxis.
Our results suggest that the feedback loop could play a regulatory role when SMN1 is present in a non-diseased state in situations.
Diseased, I find disease.
Stelvio Oncology (@StelvioOncology): Stelvio Therapeutics develops drugs to treat incurable cancers and neurodegenerative disease by driving diseased stems cells to non-diseased fates.
In our study, the sole cytokine source was the chondrocytes, unlike the situation occurring in a diseased joint where leukocytes are also present.
Instead of comparing groups of healthy and diseased animals, we employed a more practical situation encountered in the veterinary hospital environment, where hepatic lipidosis has to be differentiated from other peripartal diseases.
S. equi subsp. zooepidemicus is not normally carried by dogs, but it can probably cause disease in a situation where there is high level exposure from diseased dogs or other sources in the environment, an on-going viral infection, temperature stress, transport stress, intense exercise associated with training and competition and vaccine induced immunosuppression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com