Exact(16)
Such studies can contribute to identifying disease-specific proteins when a diseased sample of the same tissue is analyzed.
For psoriasis data sets, we used paired t-test as both normal and diseased sample came from the same patient.
For each disease, a set of candidate genes (e.g., from a linkage study) has to be defined and a relevant microarray experiment is required (e.g., diseased sample vs. reference sample).
The query is more accurately expressed as cell lines that are derived from some diseased sample.
Eight slices of exact equal size (excluding serum albumin protein band) from healthy and diseased sample sets were excised and subjected to trypsin digestion as described earlier [ 11].
From each sample, a total of 2-3.5 × 10 μm tissue was laser-dissected using four tissue sections per normal sample and two tissue sections per diseased sample.
Similar(44)
As shown in Figure 2A, PCoA separated low disease from diseased samples into two clusters along the first eigenvector.
Given the correlation with disease activity observed within diseased samples, a single-component PLS model was built within the diseased samples using the selected 12 probes.
The diseased samples contained other microbes--ones associated with fish diseases, for example--that could also play a role in the disease.
By comparing the gene expression signatures of drugs, diseased samples, and mutants, cMap was able to connect compounds, diseases, and genes through gene expression profiles.
Therefore, the methods presented here are useful for identifying subtypes of any disease provided that at least two independent microarray datasets of diseased samples are available.
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