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Both a normal model and a diseased model with BO obstruction were developed for experimentation.
The results demonstrated that the diseased model produced abnormal wrist extension and stress distribution as compared to the healthy wrist model.
We have identified the role of the suppressor of cytokine proteins (SOCS) family in combating detrimental effects of pro-inflammatory cytokines in degenerated human NP tissue as predicted by the developed diseased model.
As A, B, C, and D depend on the parameter values, they are different for each therapeutically-treated diseased model and for the healthy one.
The goal is to re-parameterize the diseased model to obtain a therapeutically treated model that, with a diseased input u tot,d, allows recovery from the diseased output to the healthy one, even in presence of uncertainty.
These data provide direct experimental evidence that the EPs generated using the protocol described herein form functional vessel networks that anastomose with vessels of the host following transplantation with beneficial outcomes, even in the diseased model.
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By providing various biochemical and biomechanical cues, healthy and diseased models at the organ level can be applied to disease progression and treatment studies.
Several biliary diseased models have been established in zebrafish, including Alagille syndrome [ 115], arthrogryposis-renal dysfunction-cholestasis syndrome [ 116], intrahepatic BA [ 117], and choledochal cysts [ 118].
B-cell Activation and T-cell Recruitment and Activation subnetworks were built to represent these immune processes and their role in COPD, and extra-cellular matrix (ECM) Degradation and Efferocytosis subnetworks were constructed by strongly modifying non diseased models to specifically comprise COPD-relevant mechanisms.
The estimates of the linear mixed effects model revealed no significant difference between (i) the healthy and diseased animals, (ii) the disease model, the two mouse strains or (iii) the diseased animals of the two groups on the log of the ratio of vesicle to particle diameter, log(RV/P).
Improvements in oral exposure by a DCU nanosuspension formulation enabled a dose-dependent efficacy study in a diseased animal model [14].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com