Sentence examples for diseased environment from inspiring English sources

Experiments that examine an entire cellular system at single or multiple states (where a state can refer to a time point, disease stage, or healthy versus diseased environment) require not only computational power, but also efficient algorithms and data models that are able to deliver reliable analyses in a short amount of time.

Before considering using stem cells for transplantation into patients it is essential to show that there is minimal risk of tumor formation, survival within a diseased environment and low levels of adverse functional effects.

It allowed researchers to access the diverse levels of biological processes in its entirety, from primary DNA sequences in coding and regulatory regions, to RNA expression in response to the physiological or diseased environment, to proteomic interactions and localizations.

First of all, probably these results cannot be generalized for other tendon derived cells from other sources; furthermore in vitro environment, rich of nutrients and oxygen is very different from the diseased environment.

We identified families and traits with greater survivorship in a diseased environment, which may now be considered as a restoration seed source, and screening processes, which managers may use prior to planting.

Third, in addition to their protective roles in mDA neurons, forced expression of Nurr1 and Foxa2 in glial cells shifts the diseased environment surrounding mDA neurons in the midbrain toward a therapeutic one by reducing pro-inflammatory cytokine levels as well as by increasing neurotrophic cytokine release.

The emphasis will be placed on the existing procedures to generate myogenic cell sources and form highly functional muscle tissues in vitro, techniques to monitor and evaluate muscle maturation and performance in vitro and in vivo, and surgical strategies to both create diseased environments and ensure implant survival and rapid integration into the host.

Unsolved issues are the integration of stem/progenitor cells in a diseased organ environment, the differentiation into epithelial tissue and the formation of tubules in a spatial environment.

For this purpose it will be important to investigate the signaling mechanisms regulating the expression of chemokine receptors and adhesion molecules involved in the trafficking of these cells to inflammatory sites [ 68– 70] and to understand how the diseased CNS environment modulate the phenotype and viability of the transplanted cells.

Interestingly, the NGF effect on MMPs is only observed in OA cartilage explants, but not in the cultured chondrocytes (e.g., lack of stimulation of MMP13 and ADAMTS-5 shown in Fig.  4e), suggesting the importance of the diseased tissue environment.

Therefore, it emerges that human ADSCs are multipotential stem cells capable of undergoing chondrogenic differentiation in vivo, and it is suggested that the diseased disc environment is able to induce the expression of both biglycan and the cartilage specific proteoglycan aggrecan.