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Do these cells initiate the disease-causing process?
It is now possible to explore the pathway, they say, in the hope of devising treatments to correct the disease-causing process.
Apart from a high proportion of non-genetic forms, even familial DCM shows a high degree of genetic heterogeneity, with different subcellular systems being involved in the disease-causing process [ 16].
First, the general "additivity-to-background" argument proposes that if an agent enhances an already existing disease-causing process, then even small exposures increase disease incidence in a linear manner.
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The aggregation of amyloid-β is thought to trigger a cascade of disease-causing processes such as inflammation, tau-tangle formation, synapse dysfunction and cell death, which ultimately leads to dementia.
An ideal drug should tackle the disease-causing processes in the most selective way, i.e. with no harm for the healthy cells.
It can be sold, that is, if the bottle carries the warning that it "may contain disease-causing microorganisms". Processed milk does not require the warning.
To provide a proof of concept for routine genomic DNA resequencing by UHTS, specifically focused on the detection of disease-causing variants, we processed a 31-kb human genomic region with three next-generation sequencing platforms and analyzed the results with a commercial, user friendly software.
Sequences have been determined for far fewer disease-causing tapeworms than for disease-causing bacteria.
As a young researcher at Yale, Collins conceived a method of hastening the laborious process of hunting disease-causing genes by skipping across long stretches of chromosomes until the suspect gene's neighborhood was located.
Disease-causing mutations that affect the splicing process are common, and testify to the importance of splicing for normal cellular function.
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CEO of Professional Science Editing for Scientists @ prosciediting.com