Sentence examples for disease transformation from inspiring English sources

To cope with increased metabolic stress, malignant cells often reprogram their biochemical pathways to enable rapid uptake and breakdown of nutrients, thus contributing to disease transformation, maintenance, and progression (Hanahan and Weinberg, 2011; Ward and Thompson, 2012).

Multiple types of cancer are marked by drastic changes to TCA cycle enzymes, which result in characteristic metabolic and epigenetic changes that are correlated with disease transformation and progression.

Recent findings show that multiple cycle enzymes are either mutated or deregulated in a broad spectrum of cancer, resulting in characteristic metabolic and epigenetic changes that are correlated with disease transformation and progression.

Homozygously mutated genes in aUPD regions that function in the initiation and progression of cancer may be associated with tumor type or subtype [8], [27], risk of disease transformation [9], patient's survival time [9], [28].

Other studies confirmed the lack of correlation related to JAK2 mutational status and disease transformation.

Additionally, patients having higher Ang-1 expression would have higher chance of disease transformation to AML.

A sophisticated custom-designed web database is used to handle clinical diagnoses, specimen tracking and reporting; all diagnoses, including disease transformations and progressions, are automatically coded to International Classification of Diseases for Oncology, 3rd Edition (ICD-O-3) (WHO, 2000).

In a large prospective multicentered cohort of 1638 PV patients, 38 (2%) transformed to MF whereby greater duration of disease impacted transformation rates.

You lay out your themes by way of introduction: "development vs. the environment, isolation vs. progress, military occupation, transmission of disease, social transformation, and the future of the city".

The main causes of death because of WM include disease progression, transformation to high-grade lymphoma or complications of therapy.

Follicular lymphoma (FL) is the most common type of indolent B-cell lymphoma, accounting for 10 20% of all malignant lymphomas (MLs) 1. FL is characterized by frequent relapses and progression to treatment-resistant disease or transformation to high-grade feature, despite initial responsiveness to chemotherapy or radiotherapy 2, 3.