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Furthermore, the reduced V394L GCase activity in the brain was below a threshold to prevent the development of central nervous system disease, since neither the V394L homozygote nor the saposin C−/− mice themselves develop progressive central nervous system disease in the time frame of these studies.
To convey meaning about risk for disease, the SAR for disease must specify a time frame for the development of disease.
On the other hand we could show that control animals that received infected MBM not subjected to the reaction (MBM sc) developed disease in a time frame comparable to a standard scrapie brain homogenate.
Patients were identified by searching the electronic files for documented diagnoses concerning lower airway diseases within the time frame.
In our present study, in which we examined ocular disease within the same time frame as their study, we were unable to recapitulate this particular phenotype of disease induced in SKG mice.
Patients with diabetic nephropathy have a much higher risk of macrovascular disease, and so a 20% reduction could be expected to affect cardiovascular disease over a longer time frame (12).
A notable constraint in the use of iPSCs for studies of basic and disease mechanisms regards the time frame of in vitro experiments and the time required for the onset of psychiatric and neurological diseases.
Therefore, it is extremely difficult to precisely study the natural history of changes observed in the early stages of the disease over a shorter time frame.
Clinical trials for preventative therapies are complex and costly endeavors focused on individuals likely to develop disease in a short time frame, randomizing them to treatment groups, and following them over time.
The confirmation of cases of brucellosis indicated that awareness among clinicians can help to diagnose this disease within a short time frame.
Naturally, in such a time frame, disease emergence and pathogen evolution are based on variations of already existing forms of microbial life.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com