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Health states developed for a study of metastatic breast cancer were adapted to describe the burden of metastatic NSCLC (progressive disease, stable disease, and responding disease).
Moreover, a disease stable for at least 6 months (SD) was observed in 28 patients (10.9 %) and 157 (60.8 %) showed PD.
The result showed that disease stable rate was 67.83%, 1, 3 and 5-year survival rate was 60.94%, 31.86% and 24.22% respectively in the treatment group.
Separate models also adjusted for platinum therapy sensitivity (resistant, sensitive, too early or missing) and treatment response (complete response, partial response, progressive disease, stable disease or missing).
Specifically, CD4+CD25+ and CD25+FoxP3+ Tregs were increased during the disease stable phase, and then decreased with accelerating disease burden.
Identifying sources of heterogeneity might permit the identification of factors that keep disease stable and therefore could be tested as treatments.
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In five other cases, the disease remained stable, with the tumor neither progressing nor shrinking.
Primary outcomes included objective response (i.e., complete response + partial response vs. progressive disease + stable disease) and overall survival (OS).
PD ; progressive disease, SD ; stable disease.
Twenty patients had concomitant cardiovascular disease in stable condition.
Disease remained stable in 14 (35%) patients (Table 2).
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CEO of Professional Science Editing for Scientists @ prosciediting.com