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I deal with this problem since 1987 and since that time have collected many tissue types in order to analyse and compare large molecular systems in tissue sections and in peripheral mononuclear blood cells (PMBC) 4. Finally, this led to the discovery of disease specific rules and the general principles of molecular systems organisation in vivo 1, 2, 4, 6.
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Grunau et al. compared Tu et al's disease specific prediction rule to many other methods [ 20].
There are two potential ways to realize this: the first is by ensuring that the proposed framework convention on global health includes disease specific articles and rules on actions that states, the private sector and other relevant parties (as defined below) must take.
Combining models which predict time-varying risks associated with hospitalization with traditional disease-specific prediction rules should theoretically result in much more accurate predictive tools which can be used to update risk estimates as an admission progresses over time.
The implementation of a disease specific score such as the CURB-65 clinical prediction rule has helped predict mortality risk and guide treatment options in patients with community acquired pneumonia.
Consequently there is a general rule that generic scales are less sensitive to change than are disease specific scales [ 6] – and which goes some way to explaining the explosion in the number of disease specific scales created over the last 10 years.
Innovation can too easily outstrip specific rules.
Eight other specific rules are laid down.
Answer: There are no specific rules.
Analyse your specific rules to spot and exploit any loopholes.
What are the specific rules on the subway?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com