11 Increasingly, models with system-, drug-, or disease-specific properties are being developed, which are more informative for predictive purposes.
Increasing interest in mechanism-based approaches has also prompted efforts towards model parameterization that enables the distinction between drug- and system or disease-specific properties, e.g., differences in the affinity to target receptors, maturational profiles and change in turnover rate of an enzyme with disease progression.
Given that the lateral entorhinal cortex is one of the first regions to be affected in Alzheimer's disease, identifying the specific properties and roles of these networks could also provide insights into disease mechanisms.
This review aimed to identify a physical performance instrument that is not disease specific that has the properties required to accurately measure and monitor the mobility of older medical patients in the acute hospital setting.
Our study intends to provide a global view of the organization of housekeeping TFs, TS TFs and miRNAs in a gene transcriptional regulatory network and to uncover specific properties of disease genes and miRNAs in the network.
Finally, the metric properties of the generic scale were compared with ABILHAND disease-specific scale properties.
To investigate if these disease specific proteins have common annotated functional properties, we performed pathway analysis (Tables S5 and S6).
AcroQoL is a disease specific questionnaire for acromegaly with good psychometric properties which were measured initially in a descriptive study with a sample of 72 patients throughout Spain.
They provide a good overview of the discriminative and evaluative properties of generic and disease specific instruments commonly used in QoL studies.
If DIF was identified, this was adjusted for by splitting items into disease specific items followed by re-analyses of measurement properties.
