Liang, P. et al. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.
By analyzing drug-induced changes in disease-specific patterns of gene expression, a new algorithm called DeMAND identifies the genes involved in implementing a drug's effects.
Qualitative conventional MRI techniques have mainly been used to define disease-specific patterns of muscle involvement.
In addition, disease-specific patterns of the impact of age were found for social functioning, pain and appetite loss.
Disease-specific patterns of glucose metabolism are generally considered to reflect neuronal dysfunction and have been demonstrated to correlate with high NFT load in different Tauopathies.
Each PET scan was Z-transformed by using automated voxel-based comparison resulting in statistical maps of disease-specific patterns of brain F-FDG uptake.
Differences between item difficulty specific to each diagnostic group and the mean item difficulty for all diagnoses were computed to identify disease-specific patterns of item difficulty.
Accordingly, we have defined patterns of exposure associated with reduced prostate cancer and increased BCC risk and considered these to determine whether distinct, disease-specific patterns of exposure can be defined.
Another long-term clinical goal would be the identification of disease-specific patterns of PPIs, which could serve as disease- or treatment-responsive biomarkers whose selective measurement leads to improved diagnostics or prognostics for common human disorders.
The PCA was performed on the differences between item difficulty specific to each diagnostic group and the average item difficulty for all diagnoses, as these differences reflect disease-specific patterns of item difficulty.
Fluorodeoxyglucose-PET imaging studies have identified disease-specific patterns of abnormal metabolic brain network activity characterized by relative increases in areas including the supplementary motor area in patients with sporadic dystonia, and manifesting and non-manifesting DYT1 gene carriers (Eidelberg et al., 1998).
