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It was intended to address bottlenecks within the national movement of quality assured human tissue towards researchers working in a disease specific context.
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To examine trans-splicing in a more disease-specific context, similar co-transfections were performed in primary SMA patient fibroblasts, 3813 cells.
Other ways of describing a CM model originate in the setting (hospital-based, hospital-to-community-based or community-based) [ 15, 16] or in the disease (disease-specific context).
Molecular connectivity maps between drugs and genes/proteins in a disease-specific context can be particularly valuable because they allow researchers to evaluate drugs against each other using their unique gene/protein-drug association profiles.
We have applied this systematic approach to discovery of potential biomarker candidates for AD, with the idea in mind that embedding of information about such putative biomarkers into a bigger disease-specific context should provide more details and explanations on potential mechanisms these candidates may be involved in.
In this regard it was necessary to break rank with typical approaches to designing disease- and symptom-specific HRQL instrumentation, since they are based on the premise that measures depend on a careful specification of disease-specific contexts and experiences.
6 7 The role of male gender as a risk factor for post-discharge hospital utilisation has been noted in several disease-specific contexts; yet, to our knowledge, no study of post-discharge hospital utilisation has focused on gender.
References: Disease specific clinical teams Context: Evidence-based self-management of chronic disease.
Participants acknowledged pressures to consider HIV within a broader chronic illness context, where disease specific services are not always accessible.
Hemodynamic monitoring is a cornerstone of care for the hemodynamically unstable patient, but it requires a manifold approach and its use is both context and disease specific.
Given that diabetes has been described as 'one of the leading threats to the health of Australians' (p.1) [ 20], it is important to examine modifiable social and psychological factors relating to the disease within their specific contexts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com